EXPERIENCE OCTOPUS

A sound microbiota in a sound body through apolipoprotein A-I and HDL

OCTOPUS project stems from the European JPI-HDHL Programme: Joint Programming Initiative-Healthy Diet, Healthy Life.

ApoA-I/HDL has been recognized to exert a beneficial role in immunity and cholesterol homeostasis, and, as a consequence, to be anti-atherogenic. The proposed project is aimed at demonstrating, for the first time, that apoA-I/HDL can also modulate intestinal homeostasis and microbiota composition and notably, that an apoA-I/HDL deficiency-driven dysbiosis can predispose to atherosclerosis development.

It has been observed that the lack of apoA-I leads to an altered microbiota composition, enriched in choline-degrading bacteria. On the other hand, gut microbiota can influence atherosclerosis development by metabolizing dietary choline.

OCTOPUS, a multidisciplinary and transnational Consortium consisting of 5 European high profile research groups with a common goal to improve cardiovascular health, will assess to what extent different levels of apoA-I/HDL modulate gut microbiota composition, intestinal homeostasis/immunity, host metabolome and may be related to atherosclerosis development.

Scansioni 3D
Campioni di sangue
Dottoressa
Pipetta inserita in Provetta
Microscopio
Grafico & stetoscopio
 

OCTOPUS AT A GLANCE

University of Milan (ITA EN)

  • Laboratory of dyslipidemias and atherosclerosis (ITA EN)

  • Laboratory of Immunity, Lipoproteins and Atherosclerosis (ITA EN)

  • Department of Clinical Sciences and Community Health (ITA EN)

Institut National de la Recherche Agronomique INRA (FR EN)

  • Food and Gut Microbiology for Human health (EN)

University of Heidelberg (EN)

Metabolon (EN)

 

MEDIA CHANNELS

OCTOPUS SOCIAL PAGES

Not only you can find the latest news about us here, but you can directly interact with us.

Each page is localized in English and in Italian.

OCTOPUS | Facebook

OCTOPUS | Twitter

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RICERCAMIX (ITA)

Il blog di comunicazione del Dipartimento di Scienze Farmacologiche e Biomolecolari dell'Università degli Studi di Milano

RicercaMIx | Blog

RicercaMIx | Facebook

RicercaMIx | Twitter

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LA STATALE | SOCIAL PAGES (ITA)

La Statale | Facebook

La Statale | Twitter

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NEWS & VIEWS

Latest Stories

 

A REVIEW ON GUT MICROBIOTA

December 27th, 2019

We've just baked a fresh review on substances made by microbiota with hormone-like properties, with a focus on cardiovascular disease. It's open access, so you can grab it ad read it right away!

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OCTOPUS PARTICIPATES IN HOT NUT 2, IN MILAN

July 12, 2019

Marco Busnelli and Andrea Baragetti (University of Milan), OCTOPUS researchers, are invited speakers in Hot Nut 2 event, "hot topics in nutrition".

Here's some pics!

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OCTOPUS GOALS OUTLINED IN UNIMI'S RESEARCH BLOG

March 5th, 2019

RicercaMIx, the official research blog of the Pharmacological and Biomolecular Sciences of the University of Milan, is kindly hosting today this blog post describing our aims and hopes. For our Italian readers!

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FIRST OCTOPUS MEETING HELD IN MILAN, JANUARY 28TH 2019

January 28th, 2019

The OCTOPUS Project has actually started! We met and talked about the Project ongoing efforts and upcoming goals.

Meeting Programme

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OCTOPUS PROJECT IS PRESENTED AT "THE CARDIORENAL AXIS: FROM RISK STRATIFICATION TO PERSONALIZED TREATMENT" SYMPOSIUM IN MANNHEIM

January 16th, 2019

The OCTOPUS activities were disclosed at the Biomarkers of the Cardiorenal Axis Meeting in Mannheim. Get the poster and it's like you were there!

POSTER OCTOPUS Mannheim Biomarkermeeting
Upcoming Events
Hot Nut 2
Fri, Apr 05
Via Luigi Mangiagalli, 25, 20133 Milano MI, Italia
Apr 05, 2019, 8:45 AM – 1:45 PM
Via Luigi Mangiagalli, 25, 20133 Milano MI, Italia
Microbiota Revolution: dove siamo oggi e quali risposte ci aspettiamo in futuro. Kind note: do NOT register through our website, write to: info@sanitanova.it, or call +390289692182
Condividi
Networking meeting
Wed, Feb 20
Paleis voor Schone Kunsten, Brussel
Feb 20, 2019, 9:00 AM – 6:00 PM
Paleis voor Schone Kunsten, Brussel, Rue Ravenstein 23, 1000 Bruxelles, Belgio
HDHL INTIMIC: Knowledge Platform on Food, Diet, Intestinal Microbiomics and Human Health
Condividi
 
Crowd Cheering
 

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