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EXPERIENCE OCTOPUS

A sound microbiota in a sound body through apolipoprotein A-I and HDL

OCTOPUS project stems from the European JPI-HDHL Programme: Joint Programming Initiative-Healthy Diet, Healthy Life.

ApoA-I/HDL has been recognized to exert a beneficial role in immunity and cholesterol homeostasis, and, as a consequence, to be anti-atherogenic. The proposed project is aimed at demonstrating, for the first time, that apoA-I/HDL can also modulate intestinal homeostasis and microbiota composition and notably, that an apoA-I/HDL deficiency-driven dysbiosis can predispose to atherosclerosis development.

It has been observed that the lack of apoA-I leads to an altered microbiota composition, enriched in choline-degrading bacteria. On the other hand, gut microbiota can influence atherosclerosis development by metabolizing dietary choline.

OCTOPUS, a multidisciplinary and transnational Consortium consisting of 5 European high profile research groups with a common goal to improve cardiovascular health, will assess to what extent different levels of apoA-I/HDL modulate gut microbiota composition, intestinal homeostasis/immunity, host metabolome and may be related to atherosclerosis development.

 

OCTOPUS AT A GLANCE

University of Milan (ITA EN)

  • Laboratory of dyslipidemias and atherosclerosis (ITA EN)

  • Laboratory of Immunity, Lipoproteins and Atherosclerosis (ITA EN)

  • Department of Clinical Sciences and Community Health (ITA EN)

Institut National de la Recherche Agronomique INRA (FR EN)

  • Food and Gut Microbiology for Human health (EN)

University of Heidelberg (EN)

Metabolon (EN)

 
 

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NEWS & VIEWS

Latest Stories

 

OCTOPUS PARTICIPATES IN HOT NUT 2, IN MILAN

Marco Busnelli and Andrea Baragetti (University of Milan), OCTOPUS researchers, are invited speakers in Hot Nut 2 event, "hot topics in nutrition".

Here's some pics!

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OCTOPUS GOALS OUTLINED IN UNIMI'S RESEARCH BLOG

RicercaMIx, the official research blog of the Pharmacological and Biomolecular Sciences of the University of Milan, is kindly hosting today this blog post describing our aims and hopes. For our Italian readers!

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FIRST OCTOPUS MEETING HELD IN MILAN, JANUARY 28TH 2019

The OCTOPUS Project has actually started! We met and talked about the Project ongoing efforts and upcoming goals.

Meeting Programme

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OCTOPUS PROJECT IS PRESENTED AT "THE CARDIORENAL AXIS: FROM RISK STRATIFICATION TO PERSONALIZED TREATMENT" SYMPOSIUM IN MANNHEIM

The OCTOPUS activities were disclosed at the Biomarkers of the Cardiorenal Axis Meeting in Mannheim. Get the poster and it's like you were there!

POSTER OCTOPUS Mannheim Biomarkermeeting
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University of Milan

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