A sound microbiota in a sound body through apolipoprotein A-I and HDL
OCTOPUS project stems from the European JPI-HDHL Programme: Joint Programming Initiative-Healthy Diet, Healthy Life.
ApoA-I/HDL has been recognized to exert a beneficial role in immunity and cholesterol homeostasis, and, as a consequence, to be anti-atherogenic. The proposed project is aimed at demonstrating, for the first time, that apoA-I/HDL can also modulate intestinal homeostasis and microbiota composition and notably, that an apoA-I/HDL deficiency-driven dysbiosis can predispose to atherosclerosis development.
It has been observed that the lack of apoA-I leads to an altered microbiota composition, enriched in choline-degrading bacteria. On the other hand, gut microbiota can influence atherosclerosis development by metabolizing dietary choline.
OCTOPUS, a multidisciplinary and transnational Consortium consisting of 5 European high profile research groups with a common goal to improve cardiovascular health, will assess to what extent different levels of apoA-I/HDL modulate gut microbiota composition, intestinal homeostasis/immunity, host metabolome and may be related to atherosclerosis development.
OCTOPUS AT A GLANCE
Food and Gut Microbiology for Human health (EN)
University of Heidelberg (EN)
NEWS & VIEWS
A REVIEW ON GUT MICROBIOTA
December 27th, 2019
We've just baked a fresh review on substances made by microbiota with hormone-like properties, with a focus on cardiovascular disease. It's open access, so you can grab it ad read it right away!
OCTOPUS PARTICIPATES IN HOT NUT 2, IN MILAN
July 12, 2019
Marco Busnelli and Andrea Baragetti (University of Milan), OCTOPUS researchers, are invited speakers in Hot Nut 2 event, "hot topics in nutrition".
Here's some pics!
OCTOPUS PROJECT IS PRESENTED AT "THE CARDIORENAL AXIS: FROM RISK STRATIFICATION TO PERSONALIZED TREATMENT" SYMPOSIUM IN MANNHEIM
January 16th, 2019
The OCTOPUS activities were disclosed at the Biomarkers of the Cardiorenal Axis Meeting in Mannheim. Get the poster and it's like you were there!